OHK conducted a forum on urban regeneration in San Francisco’s historic Ferry Building, one of America’s preeminent success stories in modern urban renewal and adaptive reuse. Hosting a group of thinkers, urbanists, economists, and planners, OHK’s Ahmed Hassan presented the 5-principle framework, which was developed to tackle the paradox of spatial strategy, innovation, and economic development in urban regeneration schemes. Fifteen case studies from San Francisco, London, and San Francisco analyzed urban policy decisions, implementation methodologies, and adaptation responses behind prominent urban rehabilitation projects since the 1950s. Interactive exercises were conducted to demonstrate the outcomes of applying the 5-principle framework over several breakout sessions. The forum concluded with a discussion on transferable lessons from the three cities and suggestions for how stakeholders in urban regeneration can incorporate the framework into regeneration planning and decision-making.